Author

J. M. Schvartzman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. H. Shih· 1 shared A. M. Intlekofer· 1 shared A. Santella· 1 shared A. Tosolini· 1 shared A. Viale· 1 shared A. Zehir· 1 shared B. Fan· 1 shared B. Wu· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. H. Shih

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2 papers

Recent·Most cited

Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting tumor mutation burden

J. M. Schvartzman, G. C. Forsyth, H. Walch, W. Chatila, A. Santella, K. Menghrajani, F. Sanchez-Vega, R. Koche, C. B. Thompson

This study shows that IDH mutations cause replication stress through heterochromatin, affecting DNA repair and PARP inhibitor response without increasing mutation burden.

bioRxiv · Aug 4, 2022 · PreprintCancer Biology

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

J. J. Harding, M. A. Lowery, A. H. Shih, J. M. Schvartzman, S. Hou, C. Famulare, M. Patel, M. Roshal, R. K. G. Do, A. Zehir, D. You, S. D. Selcuklu, A. Viale, M. S. Tallman, D. M. Hyman, , A. M. Intlekofer

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

bioRxiv · Aug 1, 2018Cancer Biology