Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts
M. Nizamoglu, F. Alleblas, T. Koster, T. Borghuis, J. M. Vonk, M. J. Thomas, E. S. White, C. Kirstin Watson, W. Timens, K. C. El Kasmi, B. N. Melgert, I. H. Heijink, J. K. Burgess
This study shows that 3D fibrotic ECM hydrogels alter fibroblast fiber organization and mechanical properties, promoting pro-fibrotic responses.
bioRxiv · Aug 9, 2023Pathology