Author

I. Mingarro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

L. Martinez-Gil· 4 shared G. Duart· 3 shared M. J. Garcia-Murria· 3 shared B. Grau· 2 shared J. Ortiz-Mateu· 2 shared L. Gadea-Salom· 2 shared A. Brun· 1 shared A. Cameron· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiochemistry

L. Martinez-Gil

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Computational design of BclxL inhibitors that target transmembrane domain interactions

G. Duart, A. Elazar, J. Weinstein, L. Gadea-Salom, J. Ortiz-Mateu, S. Fleishman, I. Mingarro, L. Martinez-Gil

This study develops a computational method to design inhibitors targeting transmembrane domain interactions of BclxL, demonstrating their ability to block anti-apoptotic effects.

bioRxiv · Nov 9, 2022Biochemistry

Identification of small molecules with virus growth enhancement properties

M. J. Garcia-Murria, L. Gadea-Salom, S. Moreno, O. Zaragoza, A. Brun, I. Mingarro, L. Martinez-Gil

This paper identifies small molecules that enhance virus growth by promoting host-virus membrane fusion, with ethynylestradiol shown to boost SARS-CoV-2 and Influenza A virus growth in vitro.

bioRxiv · Nov 8, 2022 · PreprintMicrobiology

Conformational clamping by a membrane ligand activates the EphA2 receptor

J. M. Westerfield, A. Sahoo, D. S. Alves, B. Grau, A. Cameron, M. Maxwell, J. Schuster, P. C. T. Souza, I. Mingarro, M. Buck, F. N. Barrera

The paper identifies a peptide that activates EphA2 by binding to its transmembrane domain, revealing a mechanism where the peptide acts as a molecular clamp to stabilize the active conformation of the receptor.

bioRxiv · Apr 8, 2021Biophysics

Intra-helical salt bridge contribution to membrane protein insertion

G. Duart, J. Lamb, J. Ortiz-Mateu, A. Elofsson, I. Mingarro

This study investigates intra-helical salt bridges in transmembrane helices and finds they contribute to membrane insertion energy.

bioRxiv · Feb 24, 2021Biochemistry

SARS-CoV-2 envelope protein topology in eukaryotic membranes

G. Duart, M. J. Garcia-Murria, B. Grau, J. M. Acosta-Caceres, L. Martinez-Gil, I. Mingarro

The paper determines the topology of SARS-CoV-2 E protein in eukaryotic membranes, showing it is a single-spanning protein with N-terminus extracellular and C-terminus cytoplasmic.

bioRxiv · May 27, 2020Biochemistry

A Bimolecular Multicelular complementation system for the detection of syncytium formation: A new methodology for the identification of entry inhibitors

M. J. Garcia-Murria, N. Exposito-Dominguez, I. Mingarro, L. Martinez-Gil

This paper introduces a new method to detect syncytium formation and uses it to identify entry inhibitors for Nipah virus.

bioRxiv · Jan 17, 2019Microbiology