Author

J. Machhi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Acharya· 1 shared B. D. Kevadiya· 1 shared C. Gurumurthy· 1 shared D. Stein· 1 shared E. A. Schroder· 1 shared F. Shahjin· 1 shared H. E. Gendelman· 1 shared H. Gendelman· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Acharya

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions

M. Abdelmoaty, P. Yeapuri, J. Machhi, K. Olson, F. Shahjin, Y. Zhou, L. Jingjing, K. Pandey, A. Acharya, S. Byrareddy, L. Mosley, H. Gendelman

This study investigates SARS-CoV-2 interactions with human macrophages, finding that viral exposure leads to pro-inflammatory cytokine expression and reduced type I interferon activity.

bioRxiv · Jul 7, 2021Immunology

Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination

J. Herskovitz, M. Hasan, M. Patel, W. R. Blomberg, J. D. Cohen, J. Machhi, D. Stein, E. A. Schroder, J. McMillan, C. Gurumurthy, B. D. Kevadiya, H. E. Gendelman

This paper designs CRISPR-Cas9 guide RNAs targeting HIV-1 exons to reduce viral load in infected cells without off-target effects.

bioRxiv · Jan 14, 2021Microbiology