K. Pandey

An interim exploratory biomarker analysis of a Phase 2 clinical trial to assess the impact of CT1812 in Alzheimers disease

This paper reports exploratory CSF proteomics data from a Phase 2 trial of CT1812 in Alzheimer's disease, identifying pharmacodynamic biomarkers and mechanistic insights.

SAXS DATA BASED GLYCOSYLATED MODELS OF HUMAN ALPHA-1-ACID GLYCORPROTEIN, A KEY PLAYER IN HEALTH, DISEASE AND DRUG CIRCULATION

The paper uses SAXS data and computational modeling to create glycosylated models of human alpha-1-acid glycoprotein, showing better agreement with experimental data than unglycosylated models.

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

The paper demonstrates that photoreceptors supply lactate to the RPE, supporting a metabolic exchange between these retinal cells.

Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines

This paper identifies endogenous viral elements as a new source of antigens for personalized cancer vaccines and introduces a computational pipeline to predict and test their therapeutic potential.

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health

This paper designs and in silico validates two multi-epitope vaccines against Nipah virus, incorporating CTL and HTL epitopes, B cell epitopes, and adjuvants, with potential for effective and specific immune response.

Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions

This study investigates SARS-CoV-2 interactions with human macrophages, finding that viral exposure leads to pro-inflammatory cytokine expression and reduced type I interferon activity.

Blockade of SARS-CoV-2 infection in-vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor

The paper demonstrates that SF2523, a PI3K-α/mTOR/BRD4 inhibitor, effectively blocks SARS-CoV-2 replication in vitro with an IC50 of 1.5 μM and shows synergy with remdesivir.

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

The paper investigates the dimerization behavior of F220C rhodopsin mutant and wild-type opsin in vitro and in the plasma membrane, finding that the mutant forms a unique dimer with distinct conformational features.

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

Microbiome-Gut-Brain-Axis communication influences metabolic switch in the mosquito Anopheles culicifacies

This study shows that the gut microbiome influences brain function and metabolic changes in mosquitoes through a microbiome-gut-brain axis.

Water for sterol: an unusual mechanism of sterol egress from a StARkin domain

The paper reveals a water-controlled mechanism by which sterol exits the StARkin domain through a fracture, facilitated by hydration and polar residues.