A. Acharya

Exponentially decreasing exposure of antigen generates anti-inflammatory T-cell responses

This study shows that reducing antigen exposure exponentially decreases pro-inflammatory T cell responses and promotes regulatory T cells in a mouse model of rheumatoid arthritis.

Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB

This study investigates how HROB regulates the DNA unwinding activity of the MCM8-9 helicase complex through structural and biochemical analyses.

Prevalence Of Multi Drug Resistant Bacteria On Environmental And Medical Device Surfaces Of Korea Nepal Friendship Hospital

The study assesses multidrug-resistant bacteria prevalence on environmental and medical device surfaces at Korea Nepal Friendship Hospital, finding high contamination rates and identifying key resistant species.

SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact

This study uses molecular dynamics simulations to analyze how glycans affect the opening dynamics and energetics of the SARS-CoV-2 spike protein, revealing their individual and collective roles in stabilizing the closed and open states.

Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions

This study investigates SARS-CoV-2 interactions with human macrophages, finding that viral exposure leads to pro-inflammatory cytokine expression and reduced type I interferon activity.

ACE2 glycans preferentially interact with the RBD of SARS-CoV-2 over SARS-CoV

The paper identifies differences in ACE2 glycan interactions with SARS-CoV-2 and SARS-CoV RBDs, showing N322 enhances SARS-CoV-2 binding while N90 may provide protection.

Critical interactions for SARS-CoV-2 spike protein binding to ACE2 identified by machine learning

This study identifies critical residues for SARS-CoV-2 spike protein binding to ACE2 using machine learning and free energy calculations, showing how specific mutations affect binding affinity.

Blockade of SARS-CoV-2 infection in-vitro by highly potent PI3K-α/mTOR/BRD4 inhibitor

The paper demonstrates that SF2523, a PI3K-α/mTOR/BRD4 inhibitor, effectively blocks SARS-CoV-2 replication in vitro with an IC50 of 1.5 μM and shows synergy with remdesivir.

Annulohypoxylon sp. strain MUS1, an Endophyte isolated from Taxus wallichiana Zucc. produces Taxol and Other Bioactive Metabolites

This study isolates and characterizes an endophytic fungus from Taxus wallichiana that produces Taxol and other bioactive compounds with antimicrobial, antioxidant, and anticancer properties.

Inhibitor binding influences the protonation states of histidines in SARS-CoV-2 main protease

This study uses molecular dynamics simulations to investigate how inhibitor binding affects the protonation states of histidines in SARS-CoV-2 main protease, showing their impact on structural stability and inhibitor binding.

Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration

This study shows HIV infects and integrates into lung bronchial epithelial cells, establishing latency and contributing to obstructive lung diseases in HIV-positive individuals.

Regulation of the MLH1-MLH3 endonuclease in meiosis

This paper identifies the molecular mechanism by which the MLH1-MLH3 nuclease is activated in meiosis, showing its interaction with MutSγ, EXO1, RFC, and PCNA to process recombination intermediates.

Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics

This study uses NMR and GaMD simulations to investigate allosteric motions in the CRISPR-Cas9 HNH nuclease, revealing a dynamic pathway involved in DNA cleavage activation.

Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria

This study identifies SIRT4 as an anabolic factor that activates TORC1 signalling through glutamine sparing in mitochondria, linking mitochondrial function to metabolic regulation.