Author

J. N. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

A. R. Smith· 2 shared M. S. Kay· 2 shared A. E. Siglin· 1 shared B. D. Welch· 1 shared C. P. Hill· 1 shared D. M. Eckert· 1 shared E. Jesteadt· 1 shared F. G. Whitby· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

A. R. Smith

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2 papers

Recent·Most cited

Prevention and Treatment of SHIVAD8 Infection in Rhesus Macaques by a Potent D-peptide HIV Entry Inhibitor

Y. Nishimura, J. N. Francis, O. Donau, E. Jesteadt, R. Sadjadpour, A. R. Smith, M. S. Seaman, B. D. Welch, M. A. Martin, M. S. Kay

This study demonstrates that CPT31, a D-peptide HIV entry inhibitor, prevents SHIV infection in rhesus macaques and reduces viral load in chronically infected animals.

Proceedings of the National Academy of Sciences · Aug 20, 2020Peer-reviewedMicrobiology

Characterization of resistance to a potent D-peptide HIV entry inhibitor

A. R. Smith, M. T. Weinstock, A. E. Siglin, F. G. Whitby, J. N. Francis, C. P. Hill, D. M. Eckert, M. J. Root, M. S. Kay

This study identifies mutations conferring resistance to the D-peptide HIV inhibitor PIE12-trimer and shows they reduce inhibitor affinity but also impair viral fitness.

bioRxiv · Aug 28, 2019Microbiology