Author

C. P. Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. G. Whitby· 4 shared H. L. Schubert· 2 shared J. Rutter· 2 shared P. S. Shen· 2 shared S. Fogarty· 2 shared A. A. Cluntun· 1 shared A. Blevins· 1 shared A. Dillon· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersMicrobiology

F. G. Whitby

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway

I. Cooney, H. L. Schubert, K. Cedeno, H.-J. L. Lin, J. C. Price, C. P. Hill, P. S. Shen

This study visualizes the Cdc48 AAA+ ATPase unfolding pathway using structural snapshots, revealing a hand-over-hand mechanism and the sequential ATP hydrolysis and substrate interaction between D1 and D2 subunits.

bioRxiv · May 13, 2023Biochemistry

Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites

T. J. Espino-Sanchez, H. Wienkers, R. G. Marvin, S.-a. Nalder, A. E. Garcia-Guerrero, P. E. VanNatta, Y. Jami-Alahmadi, A. M. Blackwell, F. G. Whitby, J. A. Wohlschlegel, M. T. Kieber-Emmons, C. P. Hill, P. A. Sigala

This study investigates the function of two cytochrome c homologs in the mitochondrial electron transport chain of malaria parasites, revealing that one is essential while the other has unique structural properties and is not required for blood-stage growth.

bioRxiv · Jan 23, 2023Microbiology

The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

E. L. Paine, J. J. Skalicky, F. G. Whitby, D. R. Mackay, K. S. Ullman, C. P. Hill, W. I. Sundquist

This study shows that CAPN7 interacts with IST1 at midbodies to regulate abscission and the NoCut checkpoint through proteolytic activity.

bioRxiv · Oct 18, 2022Biochemistry

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

I. B. L. Ramiro, W. E. Bjoern-Yoshimoto, J. S. Imperial, J. Gajewiak, M. Watkins, D. Taylor, W. Resager, B. Ueberheide, H. Brauner-Osborne, F. G. Whitby, C. P. Hill, L. F. Martin, A. Patwardhan, G. P. Concepcion, B. M. Olivera, H. Safavi-Hemami

The paper identifies somatostatin venom analogs from fish-hunting cone snails, showing their potential as therapeutic leads for pain, cancer, and endocrine disorders.

bioRxiv · Oct 26, 2021Biochemistry

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

K. G. Hicks, A. A. Cluntun, H. L. Schubert, S. R. Hackett, J. A. Berg, P. G. Leonard, M. A. Ajalla Aleixo, A. Blevins, P. Barta, S. Tilley, S. Fogarty, J. M. Winter, H.-C. Ahn, K. N. Allen, S. Block, , J. Rutter

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

bioRxiv · Aug 28, 2021 · PreprintBiochemistry

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

A. Song, Z. Hazlett, D. Abeykoon, J. Dortch, A. Dillon, J. Curtiss, S. B. Martinez, C. P. Hill, C. Yu, L. Huang, D. Fushman, R. E. Cohen, T. Yao

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

bioRxiv · Aug 17, 2021Biochemistry

Characterization of resistance to a potent D-peptide HIV entry inhibitor

A. R. Smith, M. T. Weinstock, A. E. Siglin, F. G. Whitby, J. N. Francis, C. P. Hill, D. M. Eckert, M. J. Root, M. S. Kay

This study identifies mutations conferring resistance to the D-peptide HIV inhibitor PIE12-trimer and shows they reduce inhibitor affinity but also impair viral fitness.

bioRxiv · Aug 28, 2019Microbiology

Vms1p is a release factor for the Ribosome-associated Quality control Complex

O. Z. Rendon, E. K. Fredrickson, C. J. Howard, J. V. Vranken, S. Fogarty, N. D. Tolley, R. Kalia, B. A. Osuna, P. S. Shen, C. P. Hill, A. Frost, J. Rutter

This study identifies Vms1p as the tRNA hydrolase that releases nascent polypeptides in the RQC pathway for degradation.

bioRxiv · Apr 14, 2018Biochemistry