Author

J. O. Obi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Deredge· 2 shared A. Diantonio· 1 shared A. E. Sestok· 1 shared A. Henrickson· 1 shared A. Scudder· 1 shared A. Soares· 1 shared A. T. Smith· 1 shared B. Demeler· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

D. Deredge

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Author profile →

3 papers

Recent·Most cited

The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.

E. Klontz, J. O. Obi, Y. Wang, G. Glendening, J. Carr, C. Tsibouris, S. Buddula, S. Nallar, A. Soares, D. Beckett, J. S. Redzic, E. Eisenmesser, C. Palm, K. Schmidt, A. Scudder, , G. A. Snyder

The paper reports the crystal structure of Acinetobacter baumannii TIR domain and its NAD+ hydrolase activity, showing conformational changes and kinetic effects upon substrate binding.

bioRxiv · May 19, 2023 · PreprintBiochemistry

Biochemical and structural characterization of the fused Bacteroides fragilis NFeoAB domain reveals a role for FeoA

A. E. Sestok, J. B. Brown, J. O. Obi, S. M. O'Sullivan, E. D. Garcin, D. Deredge, A. T. Smith

This study characterizes the Bacteroides fragilis NFeoAB fusion protein, revealing FeoA's role in stabilizing the GTP-bound form of FeoB through nucleotide-dependent interactions.

bioRxiv · Sep 29, 2021 · PreprintBiochemistry

The BRPF1 bromodomain is a molecular reader of di-acetyllysine

J. O. Obi, M. Y. Lubula, G. Cornilescu, A. Henrickson, K. McGuire, C. M. Evans, M. Phillips, S. P. Boyson, B. Demeler, J. L. Markley, K. C. Glass

This study identifies the BRPF1 bromodomain as a selective reader of di-acetyllysine modifications on histone H4 and characterizes its binding preferences and mechanisms.

bioRxiv · Feb 13, 2020Biochemistry