B. Demeler

Human calpain-3 and its structural plasticity: dissociation of a homohexamer into dimers on binding titin

This study investigates the structural plasticity of calpain-3, showing it forms a hexamer that dissociates into dimers upon binding titin.

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

DNA supercoiling-induced shapes alter minicircle hydrodynamic properties

The paper investigates how DNA supercoiling and curvature affect hydrodynamic properties using analytical ultracentrifugation and theoretical models.

p66Shc is an apoptotic rheostat whose targeted ROS inhibition improves MI outcomes

This study identifies p66Shc as a stress-dependent apoptotic rheostat and shows that reducing its pro-apoptotic ROS production improves myocardial infarction outcomes in zebrafish.

Purification and Characterization of Inorganic Pyrophosphatase for in vitro RNA Transcription

This paper demonstrates a cost-effective method to produce high-quality inorganic pyrophosphatase for in vitro RNA transcription, showing it is as effective as commercial versions and revealing its oligomeric structure.

Investigating RNA-RNA interactions through computational and biophysical analysis

This paper computationally predicts and biophysically validates long-range RNA-RNA interactions in JEV, showing the cyclization sequence drives interaction with nM affinity.

Multi-Wavelength Analytical Ultracentrifugation of Biopolymer Mixtures and Interactions

The paper demonstrates the utility of multi-wavelength analytical ultracentrifugation for analyzing complex biopolymer mixtures and interactions.

Biophysical Characterisation of Human LincRNA-p21 Sense and Antisense Alu Inverted Repeats

The paper determines the three-dimensional structures of LincRNA-p21 Alu inverted repeats using biophysical methods and integrates secondary structure data to generate high-resolution models.

Coordination of di-acetylated histone ligands by the ATAD2 bromodomain

This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.

The BRPF1 bromodomain is a molecular reader of di-acetyllysine

This study identifies the BRPF1 bromodomain as a selective reader of di-acetyllysine modifications on histone H4 and characterizes its binding preferences and mechanisms.

Nanoscale Structure Determination of Murray Valley Encephalitis and Powassan Virus Non-coding RNAs

This study examines the 5' and 3' terminal regions of Murray Valley Encephalitis and Powassan virus RNAs using biophysical and computational methods, revealing structural differences between the two regions.