Author

J. P. B. Viola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. C. de Melo· 1 shared A. C. Ferreira· 1 shared A. M. C. Faria· 1 shared A. N. A. Goncalves· 1 shared A. Rao· 1 shared A. S. Carlos· 1 shared A. Tanuri· 1 shared A. W. Schutte· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperMicrobiology

A. C. de Melo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polycomb Repressive Complex 1 subunit Cbx4 positively regulates effector responses in CD8 T cells

G. A. Melo, T. Xu, C. Caloba, A. W. Schutte, G. Brum, T. O. Passos, L. Higa, A. N. A. Goncalves, A. Tanuri, J. P. B. Viola, M. B. F. Werneck, H. Nakaya, M. E. Pipkin, G. J. Martinez, R. M. Pereira

This study shows that Cbx4 promotes effector CD8 T cell differentiation through SUMOylation and chromodomain mechanisms, impacting memory cell formation during viral infection.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Atazanavir is a competitive inhibitor of SARS-CoV-2 Mpro, impairing variants replication in vitro and in vivo

O. A. Chaves, C. Q. Sacramento, A. C. Ferreira, M. Mattos, N. Fintelman-Rodrigues, J. R. Temerozo, D. P. Pinto, G. P. E. da Silveira, L. B. da Fonseca, H. M. Pereira, A. S. Carlos, J. d. C. P. d'Avila, J. P. B. Viola, R. Q. Monteiro, L. Vazquez, , T. M. L. Souza

This study shows that atazanavir inhibits SARS-CoV-2 Mpro, effectively reducing replication of both B.1 and gamma variants in vitro and in vivo.

bioRxiv · Nov 24, 2021Pharmacology & Toxicology

The transcriptional cofactor IRF2BP2 plays a key role in T cell homeostasis and Treg cell expansion

G. P. Mognol, B. Oliveira-Vieira, N. Pinheiro-Rosa, B. C. Peixoto, M. Boroni, E. Gonzalez-Avalos, C. Secca, H. Bandukwala, A. M. C. Faria, A. Rao, J. P. B. Viola

This study shows that IRF2BP2 overexpression in T cells reduces proliferation, increases Tregs, and dampens autoimmune inflammation.

bioRxiv · Jul 29, 2021 · PreprintImmunology

SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution

J. Siqueira, L. R. Goes, B. M. Alves, P. S. de Carvalho, C. Cicala, J. Arthos, J. P. B. Viola, A. C. de Melo, M. A. Soares, INCA COVID-19 Task Force (names of participants listed in the acknowledgements section number of cha

This study compares intrahost SARS-CoV-2 genetic diversity between cancer patients and healthcare workers, finding higher diversity in cancer patients which may contribute to more severe COVID-19 outcomes.

bioRxiv · Aug 26, 2020 · PreprintMicrobiology