Author

O. A. Chaves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Q. Sacramento· 3 shared J. R. Temerozo· 3 shared N. Fintelman-Rodrigues· 3 shared P. T. Bozza· 3 shared T. M. L. Souza· 3 shared H. C. Castro-Faria-Neto· 2 shared L. Vazquez· 2 shared R. Q. Monteiro· 2 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersPharmacology & Toxicology

C. Q. Sacramento

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Atazanavir is a competitive inhibitor of SARS-CoV-2 Mpro, impairing variants replication in vitro and in vivo

O. A. Chaves, C. Q. Sacramento, A. C. Ferreira, M. Mattos, N. Fintelman-Rodrigues, J. R. Temerozo, D. P. Pinto, G. P. E. da Silveira, L. B. da Fonseca, H. M. Pereira, A. S. Carlos, J. d. C. P. d'Avila, J. P. B. Viola, R. Q. Monteiro, L. Vazquez, , T. M. L. Souza

This study shows that atazanavir inhibits SARS-CoV-2 Mpro, effectively reducing replication of both B.1 and gamma variants in vitro and in vivo.

bioRxiv · Nov 24, 2021Pharmacology & Toxicology

Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication by targeting its major protease in a non-competitive way

O. A. Chaves, C. Q. Sacramento, N. Fintelman-Rodrigues, J. R. Temerozo, F. Pereira-Dutra, D. M. Mizurini, R. Q. Monteiro, L. Vazquez, P. T. Bozza, H. C. Castro-Faria-Neto, T. M. L. Souza

This study shows apixaban inhibits SARS-CoV-2 replication by targeting its Mpro protease non-competitively, with higher potency than boceprevir.

bioRxiv · Sep 23, 2021 · PreprintMicrobiology

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

X. Wang, C. Q. Sacramento, S. Jockusch, O. A. Chaves, C. Tao, N. Fintelman-Rodrigues, M. Chien, J. R. Temerozo, X. Li, S. Kumar, W. Xie, D. J. Patel, C. Meyer, A. Garzia, T. Tuschl, , J. Ju

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

bioRxiv · Jul 21, 2021 · PreprintPharmacology & Toxicology