Polycomb Repressive Complex 1 subunit Cbx4 positively regulates effector responses in CD8 T cells
G. A. Melo, T. Xu, C. Caloba, A. W. Schutte, G. Brum, T. O. Passos, L. Higa, A. N. A. Goncalves, A. Tanuri, J. P. B. Viola, M. B. F. Werneck, H. Nakaya, M. E. Pipkin, G. J. Martinez, R. M. Pereira
This study shows that Cbx4 promotes effector CD8 T cell differentiation through SUMOylation and chromodomain mechanisms, impacting memory cell formation during viral infection.
bioRxiv · Oct 3, 2022 · PreprintImmunology