Author

J. P. Luzio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. Sienkiewicz· 1 shared D. J. van den Boomen· 1 shared D. M. van Elsland· 1 shared I. Berlin· 1 shared I. Sava· 1 shared J. J. Neefjes· 1 shared L. J. Davis· 1 shared M. L. Jongsma· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

A. Sienkiewicz

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2 papers

Recent·Most cited

Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle

I. Sava, L. J. Davis, S. R. Gray, N. A. Bright, J. P. Luzio

This study investigates the reversible assembly and disassembly of V-ATPase during lysosome regeneration in continuously fed cells, showing its role in regulating endolysosomal pH.

bioRxiv · Dec 22, 2023Cell Biology

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

D. J. van den Boomen, A. Sienkiewicz, I. Berlin, M. L. Jongsma, D. M. van Elsland, J. P. Luzio, J. J. Neefjes, P. J. Lehner

The paper identifies C18orf8 as a core component of the Mon1-Ccz1 GEF for Rab7, showing its role in Rab7 activation, endosomal LDL trafficking, and NPC1-dependent lysosomal cholesterol export.

bioRxiv · Nov 8, 2019Cell Biology