Author

J. J. Neefjes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Sienkiewicz· 1 shared B. Cabukusta· 1 shared D. J. van den Boomen· 1 shared D. M. Borras· 1 shared D. M. van Elsland· 1 shared I. Berlin· 1 shared J. P. Luzio· 1 shared M. L. Jongsma· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

A. Sienkiewicz

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Author profile →

2 papers

Recent·Most cited

CRISPR activation screening identifies VGLL3 and GATA2 as transcriptional regulators of PD-L1

R. H. Wijdeven, B. Cabukusta, X. Qiu, D. M. Borras, Y. Liang, J. J. Neefjes

The paper identifies VGLL3 and GATA2 as transcriptional regulators that upregulate PD-L1 expression through CRISPR activation screening and functional validation.

bioRxiv · Aug 18, 2021 · PreprintImmunology

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

D. J. van den Boomen, A. Sienkiewicz, I. Berlin, M. L. Jongsma, D. M. van Elsland, J. P. Luzio, J. J. Neefjes, P. J. Lehner

The paper identifies C18orf8 as a core component of the Mon1-Ccz1 GEF for Rab7, showing its role in Rab7 activation, endosomal LDL trafficking, and NPC1-dependent lysosomal cholesterol export.

bioRxiv · Nov 8, 2019Cell Biology