A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
D. J. van den Boomen, A. Sienkiewicz, I. Berlin, M. L. Jongsma, D. M. van Elsland, J. P. Luzio, J. J. Neefjes, P. J. Lehner
The paper identifies C18orf8 as a core component of the Mon1-Ccz1 GEF for Rab7, showing its role in Rab7 activation, endosomal LDL trafficking, and NPC1-dependent lysosomal cholesterol export.
bioRxiv · Nov 8, 2019Cell Biology