The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells
C. Legrand, R. Saleppico, J. Sticht, F. Lolicato, H.-M. Mueller, S. Wegehingel, E. Dimou, J. P. Steringer, H. Ewers, I. Vattulainen, C. Freund, W. Nickel
This study identifies a direct interaction between FGF2 and the Na,K-ATPase α1 subunit, showing it facilitates FGF2 membrane translocation upstream of PI(4,5)P2.
bioRxiv · Nov 1, 2019Biochemistry