C. Freund

When less is more - A fast TurboID KI approach for high sensitivity endogenous interactome mapping

The paper compares labelling enzymes for proximity labelling experiments using CRISPR-Cas9 knock-ins, showing TurboID's effectiveness in identifying interactors and cargo proteins.

T cell interaction partners of DHHC20

This study identifies DHHC20 interaction partners in T cells, showing it interacts with Gsβ1γ2 and suggests a model for its role in palmitoylation.

Quantitative analysis of MHC class II peptide exchange reveals pivotal role of peptide association rate

The paper develops a kinetic model to explain variation in HLA-DM susceptibility of MHC-II peptides and identifies two mechanisms shaping antigen presentation.

Decoding of T cell immunodominance patterns by an integrated mechanistic approach

The paper identifies immunodominant CD4+ T cell epitopes for SARS-CoV-2 antigens by integrating antigen processing systems with in silico tools, revealing distinct processing mechanisms for different antigens.

Population context drives cell-to-cell variability in interferon response in epithelial cells

The paper shows that population context affects cell-to-cell variability in interferon response in human intestinal epithelial cells, with edge cells being more responsive than central ones.

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

This paper identifies C95-C95 disulfide-bridge-mediated FGF2 dimerization as essential for membrane translocation and oligomer formation, while C77 is involved in Na,K-ATPase binding.

ADAPs intrinsically disordered region is an actin sponge regulating T cell motility

This study identifies ADAP's intrinsically disordered region as an actin sponge that regulates T cell motility by promoting actin polymerization and bundling.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

Dynamic Palmitoylation Events Following T-Cell Receptor Signaling

The paper identifies dynamic palmitoylation events in T-cells following TCR signaling, showing DHHC18 palmitoylates VAMP7 at Cys183, affecting its Golgi retention.

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells

This study identifies a direct interaction between FGF2 and the Na,K-ATPase α1 subunit, showing it facilitates FGF2 membrane translocation upstream of PI(4,5)P2.

CD4+ Th immunogenicity of the Ascaris spp. secreted products

The paper identifies a human haplotype-specific T cell epitope in Ascaris suum secreted products using an in vitro antigen processing system and quantitative proteomics.