Author

S. Wegehingel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

R. Saleppico· 3 shared W. Nickel· 3 shared C. Freund· 2 shared E. Dimou· 2 shared F. Lolicato· 2 shared H. Ewers· 2 shared H.-M. Mueller· 2 shared I. Vattulainen· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiochemistry

R. Saleppico

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Author profile →

3 papers

Recent·Most cited

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

F. Lolicato, J. Steringer, R. Saleppico, D. Beyer, J. Fernandez-Sobaberas, S. Unger, S. Klein, P. Riegerova, X. J. Schmitt, S. Kaptan, S. Wegehingel, H.-M. Mueller, C. Freund, M. Hof, R. Sachl, , W. Nickel

This paper identifies C95-C95 disulfide-bridge-mediated FGF2 dimerization as essential for membrane translocation and oligomer formation, while C77 is involved in Na,K-ATPase binding.

bioRxiv · Apr 12, 2023Biochemistry

Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2

C. Sparn, E. Dimou, A. Meyer, R. Saleppico, S. Wegehingel, M. Gerstner, S. Klaus, H. Ewers, W. Nickel

This study identifies Glypican-1 as the key factor driving unconventional secretion of FGF2, revealing its structural requirements and implications for tumor progression.

bioRxiv · Nov 11, 2021Biochemistry

The α1 subunit of the Na,K-ATPase acts upstream of PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2 from tumor cells

C. Legrand, R. Saleppico, J. Sticht, F. Lolicato, H.-M. Mueller, S. Wegehingel, E. Dimou, J. P. Steringer, H. Ewers, I. Vattulainen, C. Freund, W. Nickel

This study identifies a direct interaction between FGF2 and the Na,K-ATPase α1 subunit, showing it facilitates FGF2 membrane translocation upstream of PI(4,5)P2.

bioRxiv · Nov 1, 2019Biochemistry