PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in C. elegans
Daniela Vilasboas‐Campos, Jorge H. Fernandes, M. C. M. M. Michelle Cristina Magalhàes Melgaço Costa Costa, Joana Pereira‐Sousa, J. P. T. Lopes, Liliana Meireles-Costa, Bruna Ferreira-Lomba, Jorge Diogo Da Silva, Patricia Maciel, Andreia Teixeira‐Castro
This paper introduces PRO-FitS, a C. elegans-based phenotypic assay to identify proteostasis enhancers, validated through mTOR inhibition and serotonergic signaling effects on heat shock-induced proteotoxicity.
bioRxiv · Jan 24, 2026 · PreprintNeuroscience