Author

J. R. Iredell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:E. coli· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Petrovic Fabijan· 2 shared M. Kamruzzaman· 2 shared A. Agyekum· 1 shared A. C. Hurt· 1 shared A. Fajardo-Lubian· 1 shared A. Y. Wu· 1 shared C. Lood· 1 shared C. Reding· 1 shared

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2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersMicrobiology

A. Petrovic Fabijan

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6 papers

Recent·Most cited

The paradoxical relationship between CRISPR-Cas and phage susceptibility in Pseudomonas aeruginosa

C. Lood, E. Verkinderen, A. Petrovic Fabijan, J. R. Iredell, P.-J. Ceyssens, V. van Noort, R. Lavigne

This study examines the genomic and phenotypic effects of CRISPR-Cas systems in Pseudomonas aeruginosa, revealing a paradoxical link between CRISPR presence and increased phage susceptibility.

bioRxiv · Sep 29, 2022 · PreprintMicrobiology

L-form switching confers antibiotic, phage and stress tolerance in pathogenic Escherichia coli

A. Petrovic Fabijan, M. Kamruzzaman, D. Martinez Martin, C. Venturini, K. Mickiewicz, N. Flores Rodriguez, J. Errington, J. R. Iredell

This study shows that L-form switching in pathogenic E. coli provides tolerance to antibiotics, phages, and stress, with rapid reversion to the cell-walled state after antibiotic removal.

bioRxiv · Jun 21, 2021 · PreprintMicrobiology

Clinical Antibiotic Resistance Patterns Across 70 Countries

P. Catalan, C. Reding, J. Blair, I. Gudelj, J. R. Iredell, R. E. Beardmore

The paper analyzes global antibiotic resistance patterns using clinical data from 70 countries, identifying resistance dynamics and proposing a phase plane method to detect resistance risk.

bioRxiv · Dec 4, 2020 · PreprintMicrobiology

Specialised functions of two common plasmid mediated toxin-antitoxin systems, ccdAB and pemIK, in Enterobacteriaceae

A. Y. Wu, M. Kamruzzaman, J. R. Iredell

The paper compares sequence, expression, and plasmid stability functions of ccdAB and pemIK toxin-antitoxin systems in Enterobacteriaceae, finding differences in ccdAB and consistency in pemIK across hosts.

bioRxiv · Mar 6, 2020Microbiology

High levels of antibiotic resistance gene expression among birds living in a wastewater treatment plant

V. Rossetto Marcelino, M. Wille, A. C. Hurt, D. Gonzalez-Acuna, M. Klaassen, J.-S. Eden, M. Shi, J. R. Iredell, T. C. Sorrell, E. C. Holmes

The paper assesses antibiotic resistance gene expression in birds across different habitats, finding higher levels in wastewater treatment plant birds.

BMC Biology · Apr 8, 2019Peer-reviewedEcology

Host adaptation and convergent evolution increases antibiotic resistance without loss of virulence in a major human pathogen

A. Fajardo-Lubian, N. L. Ben Zakour, A. Agyekum, J. R. Iredell

The paper shows that antibiotic resistance in Klebsiella pneumoniae can increase without loss of virulence through changes in porin proteins, highlighting evolutionary adaptation to human hosts and antibiotic pressure.

bioRxiv · Jul 17, 2018Microbiology