I. Gudelj

Exaptation and de novo mutations transcend cryptic variations as drivers of adaptation in yeast

This study shows that yeast populations in predictable environments lose adaptive potential, with adaptation to stress driven by de novo mutations rather than pre-existing cryptic variations.

Clinical Antibiotic Resistance Patterns Across 70 Countries

The paper analyzes global antibiotic resistance patterns using clinical data from 70 countries, identifying resistance dynamics and proposing a phase plane method to detect resistance risk.

Hotspot Dosages of Most Rapid Antibiotic Resistance Evolution

This study investigates how antibiotic resistance evolves in E. coli under varying erythromycin dosages, finding that resistance increases most rapidly just below the minimal inhibitory concentration.

Canonical host-pathogen tradeoffs subverted by mutations with dual benefits

The paper shows that tradeoffs between host-parasite traits can become tradeups, supporting biodiversity through high-dimensional trait interactions.

Fluorescence photography of patterns and waves of bacterial adaptation at high antibiotic doses

The paper uses fluorescence imaging and quantitative PCR to study the spatial spread of antibiotic resistance in E. coli under high antibiotic doses, revealing complex wave patterns and nonlinear dynamics.

Global variability of the human IgG glycome

The paper analyzes global variability in IgG glycosylation across populations, finding that country of residence and socioeconomic development strongly influence glycan features and monogalactosylation levels.