The SARS-CoV-2 nucleocapsid protein associates with the replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress
K. M. Scherer, L. Mascheroni, G. W. Carnell, L. C. S. Wunderlich, S. Makarchuk, M. Brockhoff, I. Mela, A. Fernandez-Villegas, M. Barysevich, H. Stewart, M. Suau Sans, C. L. George, J. R. Lamb, G. S. Kaminski Schierle, J. L. Heeney, C. F. Kaminski
This study tracks SARS-CoV-2 structural proteins' spatiotemporal dynamics during infection, revealing nucleocapsid's early association with ER membranes and lysosome involvement in viral egress.
bioRxiv · Jun 15, 2021Microbiology