Author

I. Mela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Bioengineering· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:imaging· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Approach:microscopy & imaging analysis· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:E. coli· 3

Frequent Co-Authors

C. F. Kaminski· 7 shared G. S. Kaminski Schierle· 5 shared A. D. Stephens· 2 shared K. Bali· 2 shared M. Brockhoff· 2 shared R. M. Henderson· 2 shared S. Makarchuk· 2 shared A. Chiki· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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7 shared papersBiophysics

C. F. Kaminski

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Molecular mechanisms of liposome interactions with bacterial envelopes

A. Scheeder, M. Brockhoff, E. Ward, G. S. Kaminski Schierle, I. Mela, C. F. Kaminski

The paper investigates how fusogenic liposomes interact with Gram-negative and Gram-positive bacterial envelopes using microscopy, revealing differences in fusion and delivery mechanisms.

bioRxiv · Oct 7, 2023 · PreprintBiophysics

Multiparametric sensing of outer membrane vesicle-derived supported lipid bilayers demonstrates the specificity of bacteriophage interactions

K. Bali, Z. Lu, R. McCoy, J. Treiber, A. Savva, C. F. Kaminski, G. Salmond, A. Salleo, I. Mela, R. Monson, R. M. Owens

This study demonstrates the use of supported lipid bilayers derived from outer membrane vesicles to monitor specific bacteriophage interactions with bacterial membranes.

bioRxiv · Dec 13, 2022Bioengineering

Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations

C. W. Chung, A. J. Zhou, I. Mela, A. D. Stephens, A. Miyashita, P. H. St George-Hyslop, C. F. Kaminski, T. Knowles, G. S. Kaminski Schierle

This study investigates how mutant FUS protein accumulation affects cytoskeletal, organelle, and cellular homeostasis, linking it to cellular aging and potential senescence mechanisms.

bioRxiv · Oct 4, 2022 · PreprintBiophysics

Correlative microscopy reveals the nanoscale morphology of E. coli-derived supported lipid bilayers

K. Bali, Z. Mohamed, A.-M. Pappa, S. Daniel, C. F. Kaminski, R. Owens, I. Mela

The paper uses correlative AFM and SIM to characterize E. coli-derived supported lipid bilayers at the nanoscale, revealing their composition and interactions with membrane-binding proteins.

bioRxiv · Nov 4, 2021 · PreprintMicrobiology

The SARS-CoV-2 nucleocapsid protein associates with the replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress

K. M. Scherer, L. Mascheroni, G. W. Carnell, L. C. S. Wunderlich, S. Makarchuk, M. Brockhoff, I. Mela, A. Fernandez-Villegas, M. Barysevich, H. Stewart, M. Suau Sans, C. L. George, J. R. Lamb, G. S. Kaminski Schierle, J. L. Heeney, C. F. Kaminski

This study tracks SARS-CoV-2 structural proteins' spatiotemporal dynamics during infection, revealing nucleocapsid's early association with ER membranes and lysosome involvement in viral egress.

bioRxiv · Jun 15, 2021Microbiology

Illuminating chromatin compaction in live cells and fixed tissues using SiR-DNA fluorescence lifetime

C. Hockings, C. Poudel, K. A. Feeney, C. L. Novo, M. S. Hamouda, I. Mela, D. Fernandez-Antoran, P. P. Vallejo Ramirez, P. Rugg-Gunn, K. Chalut, C. F. Kaminski, G. S. Kaminski Schierle

This paper develops a method to measure chromatin compaction in live and fixed cells using SiR-DNA fluorescence lifetime, revealing compaction in differentiating cells and decompaction during stem cell transitions.

bioRxiv · May 2, 2020 · PreprintCell Biology

DNA origami nanostructures as a tool for the targeted destruction of bacteria

I. Mela, P. P. Vallejo-Ramirez, S. Makarchuk, G. Christie, D. M. D. Bailey, R. M. Henderson, H. Sugiyama, M. Endo, C. F. Kaminski

This study uses DNA origami nanostructures functionalized with aptamers to deliver lysozyme specifically to bacteria, showing improved efficacy against Gram-positive and Gram-negative targets.

bioRxiv · Dec 12, 2019Bioengineering

Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity

A. D. Stephens, M. Zacharopoulou, R. Moons, G. Fusco, N. Seetaloo, A. Chiki, P. J. Hooper, I. Mela, H. A. Lashuel, J. J. Philips, A. De Simone, F. D. Sobott, G. S. Kaminski Schierle

This study investigates how calcium-induced conformational changes in monomeric alpha-synuclein affect N-terminus exposure and aggregation propensity, identifying sequence-specific conformational differences as key factors.

bioRxiv · Aug 20, 2019 · PreprintBiophysics

Reconstitution of a flexible SYCP3-DNA fibre suggests a mechanism for SYCP3 coating of the meiotic chromosome axis

D. Bollschweiler, L. Radu, J. M. Plitzko, R. M. Henderson, I. Mela, L. Pellegrini

This study uses cryo-electron tomography and atomic force microscopy to show that SYCP3 forms a flexible fibre that binds DNA, suggesting a mechanism for coating the meiotic chromosome axis.

bioRxiv · Jul 14, 2018Biophysics