Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
M. H. Doran, M. J. Rynkiewicz, D. Rasicci, S. M. L. Bodt, M. E. Barry, E. Bullitt, C. M. Yengo, J. R. Moore, W. Lehman
The paper uses cryo-EM to determine high-resolution structures of human cardiac myosin bound to actin-tropomyosin in the presence and absence of Mg2+·ADP, revealing conformational changes linked to ADP release and force-sensitivity.
bioRxiv · Sep 23, 2022Biophysics