Author

E. Bullitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Approach:biophysical modeling· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

D. N. Kotton· 3 shared A. A. Wilson· 2 shared A. Emili· 2 shared A. Hinds· 2 shared C. Villacorta-Martin· 2 shared J. H. Connor· 2 shared J. Huang· 2 shared J. L. Baker· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

D. N. Kotton

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

M. H. Doran, M. J. Rynkiewicz, D. Rasicci, S. M. L. Bodt, M. E. Barry, E. Bullitt, C. M. Yengo, J. R. Moore, W. Lehman

The paper uses cryo-EM to determine high-resolution structures of human cardiac myosin bound to actin-tropomyosin in the presence and absence of Mg2+·ADP, revealing conformational changes linked to ADP release and force-sensitivity.

bioRxiv · Sep 23, 2022Biophysics

Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes

J. Kaserman, R. B. Werder, F. Wang, T. Matte, M. I. Higgins, M. Dodge, J. Lindstrom-Vautrin, A. Hinds, E. Bullitt, I. Caballero, X. Shi, R. E. Gerszten, N. Brunetti-Pierri, M. Liesa, C. Villacorta-Martin, , A. A. Wilson

This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.

bioRxiv · Feb 1, 2022 · PreprintCell Biology

Unveiling molecular interactions that stabilize bacterial adhesion pili

T. Dahlberg, J. L. Baker, E. Bullitt, M. Andersson

This study investigates the biophysical function and structural interactions of P pili from uropathogenic bacteria, revealing how subunit interactions and the N-terminal staple region stabilize the helical filament structure.

bioRxiv · Jan 20, 2022Biophysics

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

A. J. Hume, B. Heiden, J. Olejnik, E. L. Suder, S. Ross, W. A. Scoon, E. Bullitt, M. Ericsson, M. R. White, J. Turcinovic, T. T. N. Thao, R. M. Hekman, J. E. Kaserman, J. Huang, K. Alysandratos, , E. Mühlberger

This study uses recombinant Lloviu virus to investigate replication mechanisms and host interactions of an uncultured filovirus related to Ebola.

bioRxiv · Aug 2, 2021 · PreprintMicrobiology

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

D. J. Kenney, A. K. O'Connell, J. Turcinovic, P. Montanaro, R. M. Hekman, T. Tamura, A. R. Berneshawi, T. R. Cafiero, S. Al Abdullatif, B. Blum, S. I. Goldstein, B. Heller, H. P. Gertje, E. Bullitt, A. J. Trachtenberg, , F. Douam

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

bioRxiv · Jul 17, 2021 · PreprintMicrobiology

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

R. Wang, A. Hume, M. L. Beermann, C. Simone-Roach, J. Lindstrom-Vautrin, J. Le Suer, J. Huang, J. Olejnik, C. Villacorta-Martin, E. Bullitt, A. Hinds, M. Ghaedi, R. Werder, K. Abo, A. Wilson, , F. J. Hawkins

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

bioRxiv · Jul 6, 2021Cell Biology

Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress

J. L. Baker, T. Dahlberg, E. Bullitt, M. Andersson

This study investigates structural and biophysical differences in bacterial adhesion pili from urinary and intestinal pathogens, finding that disulfide bonds and alpha helices enhance resistance to stress in urinary tract bacteria.

bioRxiv · Jan 18, 2021Biophysics

Complexity and ultrastructure of infectious extracellular vesicles from cells infected by nonenveloped virus

J. E. Yang, E. D. Rossignol, D. Chang, J. Zaia, I. Forrester, H. Saulsbery, D. Nicastro, W. T. Jackson, E. Bullitt

This study identifies the complex composition and structure of infectious extracellular vesicles from non-enveloped virus-infected cells, revealing their role in viral transmission.

bioRxiv · May 2, 2019Cell Biology

Structure of a cytochrome-based bacterial nanowire

D. J. Filman, S. F. Marino, J. E. Ward, L. Yang, Z. Mester, E. Bullitt, D. R. Lovley, M. Strauss

Cryo-electron microscopy reveals the structure of a c-type cytochrome filament forming a bacterial nanowire in Geobacter sulfurreducens.

bioRxiv · Dec 10, 2018 · PreprintBiophysics