K. Sheng

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

Domain consolidation in Bacterial 50S assembly revealed by Anti-Sense Oligonucleotide Probing

The paper uses anti-sense oligonucleotides to disrupt RNA interactions in bacterial ribosome assembly, revealing intermediate structures and domain consolidation during RNP formation.

Assembly of the Bacterial Ribosome with Circularly Permuted rRNA

This study investigates bacterial ribosome assembly using circularly permuted rRNAs, revealing conserved assembly routes and domain association order.

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

Senolytic Treatment for Low Back Pain.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

Early HIV-1 Gag Assembly on Lipid Membrane with vRNA

The paper uses mass photometry to study HIV-1 Gag assembly with vRNA on lipid membranes, showing trimerization and gradual hexamer formation.

Near-Physiological in vitro Assembly of 50S Ribosomes Involves Parallel Pathways

The paper reports the assembly of 50S ribosome intermediates using in vitro reconstitution and cryo-EM, revealing parallel assembly pathways and cooperative blocks.

Unsupervised Voxel-based Segmentation reveals a Landscape of Bacterial Ribosome Large Subunit Early Assembly

The paper uses cryo-EM and a new segmentation method to reveal the early assembly pathway of bacterial ribosome large subunit, identifying cooperative blocks and a unified maturation landscape.

Efficient algorithms for designing maximally sized orthogonal DNA sequence libraries

The paper introduces SeqWalk, an efficient algorithm for designing large orthogonal DNA sequence libraries by minimizing sequence symmetry in a de Bruijn graph representation.

Connexin 43 confers chemoresistance through activating PI3K

This study identifies Cx43's role in glioblastoma chemoresistance by activating PI3K signaling, and shows that targeting Cx43 and PI3K{beta} restores temozolomide sensitivity.