Mother centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly
S.-S. Wong, Z. M. Wilmott, S. Saurya, I. Alvarez-Rodrigo, F. Y. Zhou, K.-Y. Chau, A. Goriely, J. Raff
bioRxiv · Oct 26, 2021Cell Biology
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J. Raff
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Ana1 recruits PLK1 to mother centrioles to promote mitotic PCM assembly and centriole elongation
I. Alvarez-Rodrigo, A. Wainman, J. Raff
The paper identifies Ana1 as a protein that recruits PLK1 to mother centrioles, facilitating mitotic PCM assembly and centriole elongation through a phosphorylation cascade.
bioRxiv · Aug 11, 2020Cell Biology
Drosophila PLP forms centriolar-clouds that promote centriole stability, cohesion and MT nucleation
H. Roque, M. Pratt, E. Johnson, J. Raff
This study investigates the role of Drosophila PLP in centriole structure and function, identifying its role in forming pericentriolar clouds that support centriole stability, cohesion, and microtubule nucleation.
bioRxiv · Jul 10, 2017Cell Biology