Author

J. S. Condeelis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Entenberg· 6 shared C. L. Duran· 4 shared M. H. Oktay· 4 shared V. P. Sharma· 4 shared C. R. Surve· 2 shared D. Cox· 2 shared G. S. Karagiannis· 2 shared X. Chen· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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6 shared papersCancer Biology

D. Entenberg

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Author profile →

6 papers

Recent·Most cited

Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination

C. R. Surve, C. L. Duran, X. Ye, X. Chen, Y. Lin, A. S. Harney, Y. Wang, V. P. Sharma, E. R. Stanley, D. Cox, J. C. McAuliffe, D. Entenberg, M. H. Oktay, J. S. Condeelis

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

bioRxiv · Jan 8, 2024 · PreprintCancer Biology

Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections

A. Genna, C. L. Duran, D. Entenberg, J. S. Condeelis, D. Cox

This study shows macrophages promote tumor cell extravasation via thin membranous connections (TMCs) in vitro and in vivo, and reducing TMC formation decreases metastasis.

bioRxiv · Feb 16, 2023 · PreprintCancer Biology

Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

C. L. Duran, G. S. Karagiannis, X. Chen, V. P. Sharma, D. Entenberg, J. S. Condeelis, M. H. Oktay

This study identifies a mechanism by which macrophages induce MenaINV expression in breast cancer cells through cooperative NF-κB and Notch1 signaling, leading to increased metastasis.

bioRxiv · Jan 3, 2023Cancer Biology

Interleukin 4 controls the role of macrophages in pulmonary metastatic tumor cell seeding and growth

C. A. Rodriguez-Tirado, D. Entenberg, J. Li, B.-Z. Qian, J. S. Condeelis, J. W. Pollard

This study shows that IL4 signaling in macrophages promotes lung metastasis by enhancing tumor cell extravasation and regulating pro-tumoral gene expression.

bioRxiv · Dec 28, 2021 · PreprintCancer Biology

SUN-MKL1 crosstalk regulates nuclear deformation and fast motility of breast carcinoma cells in fibrillar ECM micro-environment

V. P. Sharma, J. Williams, E. Leung, J. Sanders, R. Eddy, J. Castracane, M. H. Oktay, D. Entenberg, J. S. Condeelis

bioRxiv · Nov 24, 2020Cancer Biology

Live imaging of breast tumors shows macrophage-dependent induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

V. P. Sharma, B. Tang, Y. Wang, G. S. Karagiannis, E. A. Xue, D. Entenberg, L. Borriello, A. Coste, C. L. Duran, R. J. Eddy, G. Kim, X. Ye, J. G. Jones, E. Grunblatt, N. Agi, , M. H. Oktay

The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.

bioRxiv · Sep 18, 2020 · PreprintCancer Biology