Author

E. Leung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Tomek· 2 shared A. A. Iwanowicz· 1 shared b. baguley· 1 shared C. J. Der· 1 shared C. L. Hisey· 1 shared D. Entenberg· 1 shared D. S. Karanewsky· 1 shared E. Cooper· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

P. Tomek

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn, K. Drizyte-Miller, E. Leung, Y. E. Greer, P. R. Graves, A. A. Iwanowicz, H. Ashamalla, E. Holmuhamedov, H. Lang, D. S. Karanewsky, C. J. Der, W. A. Houry, S. Lipkowitz, , L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

bioRxiv · Feb 14, 2022Pharmacology & Toxicology

Conjugation of palbociclib with MHI-148 has an increased cytotoxic effect for breast cancer cells and an altered mechanism of action

E. Leung, P. Tomek, M. Tercel, J. Reynisson, T. I. H. Park, E. Cooper, W. A. Denny, P. J. Choi, J. Jose

This study conjugates palbociclib with MHI-148, showing increased cytotoxicity in breast cancer cells but a different mechanism of action compared to palbociclib alone.

bioRxiv · Nov 2, 2021 · PreprintCancer Biology

Effect of SFX-01 on proliferation of human glioblastoma cell lines

E. Leung, E. Wright, b. baguley

This study evaluates SFX-01's effect on glioblastoma cell proliferation, showing it inhibits growth in both monolayer and spheroid models, with IC50 values similar to reference SFN.

bioRxiv · Sep 14, 2021 · PreprintCancer Biology

SUN-MKL1 crosstalk regulates nuclear deformation and fast motility of breast carcinoma cells in fibrillar ECM micro-environment

V. P. Sharma, J. Williams, E. Leung, J. Sanders, R. Eddy, J. Castracane, M. H. Oktay, D. Entenberg, J. S. Condeelis

bioRxiv · Nov 24, 2020Cancer Biology

Towards establishing Extracellular Vesicle-associated RNAs as biomarkers for HER2+ breast cancer

C. L. Hisey, P. Tomek, Y. N. Nursalim, L. W. Chamley, E. Leung

The paper develops a method to increase EV yield from breast cancer cells and identifies potential RNA biomarkers for HER2+ breast cancer.

bioRxiv · Sep 27, 2020Cancer Biology