J. S. Madsen

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

This study shows type IV-A3 CRISPR-Cas systems use host adaptation machinery to update their CRISPR arrays and interfere with plasmid and phage transfer, supporting their role in plasmid competition.

An easily modifiable conjugative plasmid for studying horizontal gene transfer

This paper develops a conjugative plasmid model with an attTn7 site for efficient genetic modification to study horizontal gene transfer.

CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids

The paper investigates CRISPR-Cas systems on bacterial and archaeal plasmids, finding they are widespread, diverse, and involved in plasmid-plasmid conflicts.

Deep Learning Shows Cellular Senescence Is a Barrier to Cancer Development

This study uses deep learning to predict cellular senescence from cell morphology and finds higher senescence rates correlate with lower cancer incidence.

Adaptive evolution of phenotypic switching during environmental change

This study shows that in changing environments, generalist bacteria outcompete specialists initially but are later outcompeted by specialists under local competition, with c-di-GMP system mutations driving phenotypic adaptation.

Plasmids persist in a microbial community by providing fitness benefit to multiple phylotypes

This study shows that plasmids can persist in microbial communities by providing fitness benefits to multiple bacterial phylotypes, enabling long-term community-wide access to antibiotic resistance genes.

Developing single molecule methods for measuring the pathway proteins ERK, AKT, cyclin d and p70s6k in localized colon cancer in relation to mutation status

This study quantifies pathway proteins in colon cancer tissue to assess their correlation with mutation status and survival outcomes.