Author

P. C. Fineran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:bacteria (other)· 6 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:genetic perturbation / CRISPR· 2 Assay:metagenomics· 2 Organism:multiple species· 2

Frequent Co-Authors

S. A. Jackson· 4 shared L. M. Malone· 3 shared R. D. Fagerlund· 3 shared S. L. Warring· 3 shared D. Mayo-Munoz· 2 shared E. R. Westra· 2 shared J. Jayaraman· 2 shared L. F. Gumy· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

S. A. Jackson

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Author profile →

11 papers

Recent·Most cited

New antiviral defences are genetically embedded within prokaryotic immune systems.

L. J. Payne, T. C. D. Hughes, P. C. Fineran, S. A. Jackson

The paper identifies new antiviral defence systems in prokaryotes by analyzing genetic embedding of uncharacterized genes within known defence systems.

bioRxiv · Jan 29, 2024 · PreprintMicrobiology

KatG inactivation generates vulnerabilities in isoniazid resistant strains of Mycobacterium tuberculosis

X. Wang, W. J. Jowsey, C.-Y. Cheung, N. E. Seeto, N. J. Waller, M. T. Chrisp, A. L. Peterson, B. Nijagal, P. C. Fineran, G. M. Cook, S. A. Jackson, M. B. McNeil

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology

Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection

D. Mayo-Munoz, L. M. Smith, C. Garcia-Doval, L. M. Malone, K. R. Harding, S. A. Jackson, H. G. Hampton, R. D. Fagerlund, L. F. Gumy, P. C. Fineran

The paper shows type III CRISPR-Cas systems provide immunity against jumbo phages by degrading bacterial DNA and disrupting phage replication through an accessory nuclease, leading to abortive infection.

bioRxiv · Jun 20, 2022Microbiology

Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex

E. A. Schwartz, J. P. Bravo, L. A. Macias, C. L. McCafferty, T. L. Dangerfield, J. N. Walker, J. S. Brodbelt, P. C. Fineran, R. D. Fagerlund, D. W. Taylor

The paper determines the structure of a type III-D CRISPR-Cas effector complex and characterizes its RNA cleavage mechanism, revealing how multi-subunit fusion proteins assemble into an active RNA endonuclease.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

A lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance

S. L. Warring, L. M. Malone, J. Jayaraman, R. A. Easingwood, L. A. Rigano, R. A. Frampton, S. B. Visnovsky, S. M. Addison, L. Hernandez, A. R. Pitman, E. Lopez Acedo, T. Kleffmann, M. D. Templeton, M. Bostina, P. C. Fineran

This paper studies a phage that infects a plant pathogen, showing it uses LPS as a receptor and can evolve to bypass bacterial resistance.

bioRxiv · Jun 10, 2022Microbiology

High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems

S. Meaden, A. Biswas, K. Arkhipova, S. E. Morales, B. E. Dutilh, E. R. Westra, P. C. Fineran

The paper examines the relationship between viral abundance and diversity and CRISPR-Cas prevalence across microbial ecosystems using metagenomic data.

bioRxiv · Jun 24, 2021Microbiology

CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids

R. Pinilla-Redondo, J. Russel, D. Mayo-Munoz, S. A. Shah, R. A. Garrett, J. Nesme, J. S. Madsen, P. C. Fineran, S. J. Soerensen

The paper investigates CRISPR-Cas systems on bacterial and archaeal plasmids, finding they are widespread, diverse, and involved in plasmid-plasmid conflicts.

bioRxiv · Jun 4, 2021Microbiology

Discovery of multiple anti-CRISPRs uncovers anti-defense gene clustering in mobile genetic elements

R. Pinilla-Redondo, S. Shehreen, N. D. Marino, R. D. Fagerlund, C. M. Brown, S. J. Soerensen, P. C. Fineran, J. Bondy-Denomy

The paper identifies 11 new anti-CRISPR genes in Enterobacteriaceae and Pseudomonas, revealing their clustering with other anti-defense genes in genomic regions called 'anti-defense islands'.

bioRxiv · May 22, 2020Microbiology

Variation at the common polysaccharide antigen locus drives lipopolysaccharide diversity within the P. syringae species complex

J. Jayaraman, W. T. Jones, D. Harvey, L. M. Hemara, H. C. McCann, M. Yoon, S. L. Warring, P. C. Fineran, C. H. Mesarich, M. D. Templeton

The paper identifies a genetic locus driving LPS diversity in P. syringae by analyzing allelic variation in the TET operon and its impact on LPS structure and immunogenicity.

bioRxiv · Mar 31, 2020Microbiology

A nucleus-forming jumbophage evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity

L. M. Malone, S. L. Warring, S. A. Jackson, C. Warnecke, P. P. Gardner, L. F. Gumy, P. C. Fineran

The paper identifies a jumbophage that evades DNA-targeting CRISPR-Cas systems but is vulnerable to type III RNA-based immunity, revealing the role of nucleus-like structures in immune evasion.

bioRxiv · Sep 25, 2019Microbiology

Type I-F CRISPR-Cas resistance against virulent phage infection triggers abortive infection and provides population-level immunity

B. N. Watson, R. B. Vercoe, G. P. Salmond, E. R. Westra, R. H. Staals, P. C. Fineran

This study shows that Type I CRISPR-Cas in Pectobacterium atrosepticum causes abortive infection against virulent phages, leading to population-level immunity.

bioRxiv · Jun 21, 2019Microbiology