BiochemistrybioRxiv
Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike
R. N. Kirchdoerfer, N. Wang, J. Pallesen…·A. B. Ward
This study uses cryo-EM to show that ACE2 binding and trypsin cleavage of SARS-CoV spike protein do not cause major conformational changes or expose the S2 cleavage site.