J. S. O'Neill

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.

This study investigates circadian regulation of protein turnover and proteome renewal, finding that synthesis and degradation rhythms consolidate proteome renewal while minimizing compositional changes.

The paper identifies daily haemoglobin oxidation rhythms in red blood cells and links them to core body temperature regulation, independent of circadian mutations in nucleated cells.

This study quantifies the relative contributions of diurnal and circadian regulation to proteome dynamics in Ostreococcus tauri, revealing distinct rhythmic patterns and post-transcriptional regulation.

The paper shows that circadian rhythms persist in mice lacking CRY, suggesting that transcriptional feedback is not essential for timekeeping, but rather contributes to robustness.

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.

This study compares the circadian proteome and phosphoproteome of wild-type and CRY-deficient fibroblast cells, finding increased circadian-regulated proteins and stress sensitivity in CRY-deficient cells.