Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
G. Li, C. Lee, A. T. Read, K. Wang, I. Navarro, J. Cui, K. Young, R. Gorijavolu, T. Sulchek, C. Kopczynski, S. Farsiu, J. Samples, P. Challa, C. R. Ethier, W. D. Stamer
This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.
bioRxiv · Jul 17, 2020Physiology