C. R. Ethier

MAGNETICALLY STEERED CELL THERAPY FOR REDUCTION OF INTRAOCULAR PRESSURE AS A TREATMENT STRATEGY FOR OPEN-ANGLE GLAUCOMA

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

A Method for Analyzing AFM Force Mapping Data Obtained from Soft Tissue Cryosections

The paper describes an AFM force mapping pipeline to analyze mechanical properties of cryosectioned soft tissues, showing that repeated measurements, outlier exclusion, and log-normal transformation improve reliability.

Aging and intraocular pressure homeostasis in mice

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway

This study investigates the role of pectinate ligaments in maintaining the biomechanical stability of the aqueous outflow pathway in mice across different ages.

The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study

This study uses computational modeling to show that negative periocular pressure reduces optic nerve head strain and increases corneal strain, suggesting potential biomechanical benefits for glaucoma treatment.

In vivo Biomechanical Assessment of Iridial Deformations and Muscle Contractions in Human Eyes

The paper assesses iridial biomechanical deformations and muscle contractions in human eyes using near-infrared movies from the pupillary light reflex to study their role in primary angle-closure glaucoma.

Assessment of the Viscoelastic Mechanical Properties of the Porcine Optic Nerve Head using Micromechanical Testing and Finite Element Modeling

This study measures the viscoelastic properties of porcine optic nerve heads using micromechanical testing and finite element modeling, revealing quadrant-specific mechanical characteristics.

Identifiability of Tissue Material Parameters from Uniaxial Tests using Multi-start Optimization

This paper assesses the identifiability of tissue material parameters from uniaxial tests using synthetic data and multi-start optimization, finding that not all parameters are uniquely identifiable.

Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.

A Biphasic Approach for Characterizing Tensile, Compressive, and Hydraulic Properties of the Sclera

This paper measures biomechanical properties of sclera in pig and mouse using unconfined compression testing and poroelastic theory, showing comparable results to traditional methods and demonstrating the technique's applicability to mice.