Author

P. Challa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

K. L. Saar· 2 shared T. P. J. Knowles· 2 shared A. K. Jayaram· 1 shared A. Pujari· 1 shared A. S. Morgunov· 1 shared A. T. Read· 1 shared C. G. Taylor· 1 shared C. Kopczynski· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

K. L. Saar

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Author profile →

3 papers

Recent·Most cited

Machine learning aided top-down protein identification on a microfluidic platform

Y. Zhang, M. Wright, K. L. Saar, P. Challa, A. S. Morgunov, Q. A. E. Peter, S. Devenish, C. M. Dobson, T. P. J. Knowles

This paper demonstrates a microfluidic platform that generates multidimensional protein fingerprints, enabling high-accuracy classification using machine learning, even when single-dimensional classification fails.

bioRxiv · Nov 14, 2020 · PreprintBiophysics

Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

G. Li, C. Lee, A. T. Read, K. Wang, I. Navarro, J. Cui, K. Young, R. Gorijavolu, T. Sulchek, C. Kopczynski, S. Farsiu, J. Samples, P. Challa, C. R. Ethier, W. D. Stamer

This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.

bioRxiv · Jul 17, 2020Physiology

Direct digital sensing of protein biomarkers in solution

G. Krainer, K. L. Saar, W. E. Arter, T. J. Welsh, M. A. Czekalska, R. P. B. Jacquat, Q. Peter, W. Traberg-Christensen, A. Pujari, A. K. Jayaram, P. Challa, C. G. Taylor, L.-M. van der Linden, T. Franzmann, R. M. Owens, , T. P. J. Knowles

This paper introduces a single-molecule microfluidic platform for digital protein biomarker detection, demonstrating its ability to quantify protein concentrations and provide insights beyond traditional immunoassays.

bioRxiv · May 24, 2020 · PreprintBiophysics