W. D. Stamer

Aging and intraocular pressure homeostasis in mice

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway

This study investigates the role of pectinate ligaments in maintaining the biomechanical stability of the aqueous outflow pathway in mice across different ages.

Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology

This study investigates how ECM stiffening affects YAP mechanosignaling in SC cells and shows that disrupting YAP signaling improves outflow facility in glaucoma.

Polarized Desmosome and Hemidesmosome Shedding via Exosomes is an Early Indicator of Outer Blood-Retina Barrier Dysfunction

The paper shows that oxidative stress in RPE cells leads to exosome-mediated shedding of desmosomes and hemidesmosomes, indicating early blood-retinal barrier dysfunction.

YAP/TAZ mediate TGFβ2-induced Schlemm's canal cell dysfunction

This study shows that YAP/TAZ signaling is involved in TGFβ2-induced dysfunction of Schlemm's canal cells and that inhibiting YAP/TAZ can reduce this dysfunction.

Extracellular matrix stiffness and TGFβ2 regulate YAP/TAZ activity in human trabecular meshwork cells

This study shows that ECM stiffness and TGFβ2 regulate YAP/TAZ activity in HTM cells, contributing to glaucoma progression.

Surface Engineering of FLT4-Targeted Nanocarriers Enhances Cell-Softening Glaucoma Therapy

This paper develops FLT4-targeted nanocarriers for glaucoma therapy, showing improved IOP reduction and targeted delivery to Schlemms canal cells.

A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling

This paper develops a biomimetic HTM hydrogel model to study glaucoma pathology and test therapeutic interventions.

Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.

Mechanotransduction and dynamic outflow regulation in trabecular meshwork requires Piezo1 channels

This study identifies Piezo1 channels as critical for mechanosensitivity in trabecular meshwork cells, showing their role in pressure response, calcium signaling, and outflow regulation.

Molecular taxonomy of human ocular outflow tissues defined by single cell transcriptomics

This study uses single-cell RNA sequencing to create a cell atlas of human ocular outflow tissues, identifying 12 cell types and mapping glaucoma-related gene expression.

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

The paper compares the sensitivity of four probe technologies to measure biomechanical properties of different cellular regions in two cell types under various perturbations.