Regulation of Epithelial HIF by Probiotic Escherichia coli
Alexander S. Dowdell, Rebecca L. Roer, Geetha Bhagavatula, Ian M. Cartwright, Rachel H. Cohen, Jacob A. Countess, Samuel D. Koch, J. Scott Lee, Calen A. Steiner, Noah T Thompson, Zachary F. Villamaria, Nichole M. Welch, Corey S. Worledge, Liheng Zhou, Sean P. Colgan
This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.
bioRxiv · May 14, 2025 · PreprintCell Biology