Author

Rachel H. Cohen

University of Colorado AnschutzORCID 0000-0002-2533-3472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander S. DowdelliD· 2 shared Geetha BhagavatulaiD· 2 shared Ian M. CartwrightiD· 2 shared Jacob A. CountessiD· 2 shared Liheng ZhouiD· 2 shared Rebecca L. RoeriD· 2 shared Sean P. ColganiD· 2 shared Alfredo OrnelasiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Alexander S. DowdellORCID

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2 papers

Recent·Most cited

Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa

Alfredo Ornelas, Jacob A. Countess, Ji Yeon Kim, Rachel H. Cohen, Brittany Gomez, Rebecca L. Roer, Faiz Minhajuddin, Kiranmayee Yenugudhati Vijaya Sai, Liheng Zhou, Julia L.M. Dunn, Caleb Chandler, Philip Reigan, Ian M. Cartwright, Caroline H. T. Hall, Geetha Bhagavatula, , Sean P. Colgan

This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.

Proceedings of the National Academy of Sciences · Apr 9, 2026Peer-reviewedMolecular Biology

Regulation of Epithelial HIF by Probiotic Escherichia coli

Alexander S. Dowdell, Rebecca L. Roer, Geetha Bhagavatula, Ian M. Cartwright, Rachel H. Cohen, Jacob A. Countess, Samuel D. Koch, J. Scott Lee, Calen A. Steiner, Noah T Thompson, Zachary F. Villamaria, Nichole M. Welch, Corey S. Worledge, Liheng Zhou, Sean P. Colgan

This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.

bioRxiv · May 14, 2025 · PreprintCell Biology