Author

Calen A. Steiner

University of Colorado AnschutzORCID 0000-0002-1964-010XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Geetha BhagavatulaiD· 2 shared Ian M. CartwrightiD· 2 shared Sean P. ColganiD· 2 shared Alexander S. DowdelliD· 1 shared Alyse W. StaleyiD· 1 shared Arianne L. TheissiD· 1 shared Caroline H. T. HalliD· 1 shared Corey S. WorledgeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Geetha BhagavatulaORCID

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2 papers

Recent·Most cited

Epithelial HO-1 regulates iron availability and promotes colonic tumorigenesis in a context-dependent manner

Rosemary C. Callahan, Jillian Curry, Geetha Bhagavatula, Alyse W. Staley, Rachel E.M. Schaefer, Faiz Minhajuddin, Liheng Zhou, Rane M. Neuhart, Shaikh Muhammad Atif, David J. Orlicky, Ian M. Cartwright, Mark E. Gerich, Calen A. Steiner, Arianne L. Theiss, Caroline H. T. Hall, , Joseph C. Onyiah

This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.

JCI Insight · Dec 17, 2025Peer-reviewedCancer Biology

Regulation of Epithelial HIF by Probiotic Escherichia coli

Alexander S. Dowdell, Rebecca L. Roer, Geetha Bhagavatula, Ian M. Cartwright, Rachel H. Cohen, Jacob A. Countess, Samuel D. Koch, J. Scott Lee, Calen A. Steiner, Noah T Thompson, Zachary F. Villamaria, Nichole M. Welch, Corey S. Worledge, Liheng Zhou, Sean P. Colgan

This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.

bioRxiv · May 14, 2025 · PreprintCell Biology