Author

J. Sengstack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Woerman· 1 shared C. Deng· 1 shared C. Nowotny· 1 shared D. R. Southworth· 1 shared E. N. Munoz· 1 shared E. Tse· 1 shared H. Li· 1 shared I. E. Johnson· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

A. Woerman

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2 papers

Recent·Most cited

Systematic Approach Identifies Multiple Transcription Factor Perturbations That Rejuvenate Replicatively Aged Human Skin Fibroblasts

J. Sengstack, J. Zheng, M. Mobaraki, J. Lin, C. Deng, H. Li

The paper identifies multiple transcription factor perturbations that rejuvenate aged human skin fibroblasts through a Perturb-seq screen and validation of aging hallmarks.

bioRxiv · Nov 20, 2022Cell Biology

PIKfyve inhibition blocks endolysosomal escape of α-synuclein fibrils and spread of α-synuclein aggregation

S. K. See, M. Chen, S. Bax, R. Tian, A. Woerman, E. Tse, I. E. Johnson, C. Nowotny, E. N. Munoz, J. Sengstack, D. R. Southworth, J. E. Gestwicki, M. D. Leonetti, M. Kampmann

The paper identifies PIKfyve inhibition as a strategy to block α-synuclein fibril escape from lysosomes, reducing aggregation spread in a human cell model.

bioRxiv · Jan 21, 2021 · PreprintCell Biology