J. Zheng

Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments

The paper introduces a competitive partitioning model to distinguish effects of species interactions on ecosystem productivity using simulated and experimental data.

DNA damage drives antigen diversification through mosaic VSG formation in Trypanosoma brucei

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

Endophilin-Lamellipodin-VASP, key components in fast endophilin-mediated endocytosis, control actin polymerization within liquid-like condensates.

This study identifies Endophilin, Lamellipodin, and VASP as key components in fast endophilin-mediated endocytosis that regulate actin polymerization through liquid-like condensates.

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota.

Phase Contrast Tomography (PCT)

This paper introduces phase contrast tomography (PCT) for 3D phase imaging, demonstrating its high resolution and stability for imaging microspheres and sub-organelles.

Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclampsia-like Phenotypes: Transcriptome, Phosphoproteome, and Cell Functions

This study shows that an endogenous AhR ligand induces PE-like phenotypes by altering transcriptome, phosphoproteome, and vascular functions in pregnant rats and HUVECs.

Increased multiplexity in optical tissue clearing-based 3D immunofluorescence microscopy of the tumor microenvironment by LED photobleaching

This paper introduces an LED photobleaching method to enhance 3D immunofluorescence microscopy multiplexity for tumor microenvironment analysis, achieving 8-plex imaging.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

Genomic fingerprints of the world's soil ecosystems

This paper analyzes 1512 soil metagenomes to uncover genomic patterns of soil microbiomes across environmental factors and biomes, revealing shifts in microbial functions and biogeographical distributions.

Ubiquitin Ligase MARCH5 Regulates the Formation of Mitochondria Derived Pre-peroxisomes

This study identifies MARCH5 as a regulator of mitochondria-derived pre-peroxisomes by impeding PEX3-containing vesicle budding.

How Much Does TRPV1 Deviate from An Ideal MWC-Type Protein

The paper quantifies how well the MWC model predicts TRPV1 activation by vanilloids, finding a small subunit position effect not seen in hemoglobin.

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

This study identifies senescent osteoclasts in spinal models as contributors to pain through nerve growth and vessel formation, showing their removal reduces hypersensitivity.

TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein

This study identifies TRIM72 as a host factor that restricts lyssavirus infection by promoting ubiquitination and proteasomal degradation of the viral matrix protein.

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.

Enhancement of Protein Stability by Quenching Millisecond Conformational Dynamics

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

Metagenomic survey of antimicrobial resistance (AMR) in Maryland surface waters differentiated by high and low human impact

The paper surveys antimicrobial resistance in Maryland surface waters, finding higher prevalence of beta-lactamase genes in high human impact areas.

MicroRNA-29 Differentially Mediates Preeclampsia-Dysregulated Cellular Responses to Cytokines in Female and Male Fetal Endothelial Cells

This study identifies miR-29a/c-3p dysregulation in PE as sex-specific modulator of cytokine responses in fetal endothelial cells, with distinct effects on monolayer integrity and proliferation.

Salactin, a dynamically unstable actin homolog in Haloarchaea

This study identifies and characterizes Salactin, an actin homolog in Haloarchaea, showing it forms dynamically unstable filaments and is involved in chromosomal segregation under low-ploidy conditions.

Long-term reliable neural decoding based on flexible implantable microelectronics and machine learning for seizure prediction application

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

SUMOylation of PTEN promotes DNA end resection through directly dephosphorylating 53BP1 in homologous recombination repair

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

Chromosome-level genomes of multicellular algal sisters to land plants illuminate signaling network evolution

The paper sequenced four Zygnematophyceae algal genomes to study signaling network evolution, finding expanded genes for multicellularity and environmental response.

TRPV1 Opening is Stabilized Equally by Its Four Subunits

The paper measures how RTX binding to TRPV1 subunits affects channel opening, finding each subunit contributes equally to activation energy.

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Systematic Approach Identifies Multiple Transcription Factor Perturbations That Rejuvenate Replicatively Aged Human Skin Fibroblasts

The paper identifies multiple transcription factor perturbations that rejuvenate aged human skin fibroblasts through a Perturb-seq screen and validation of aging hallmarks.

Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis

This study identifies the mechanism of contractile ring mechanosensation and its anillin-dependent tuning during asymmetric ring closure in C. elegans embryos.