Y. Peleg

A new targeting motif for endoplasmic reticulum surface proteins

The paper identifies an amphipathic helix as a targeting motif for ER surface proteins in yeast and humans, showing its conservation and role in membrane localization.

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

Determining the targeting specificity of the selective peroxisomal targeting factor Pex9

The paper investigates the targeting specificity of Pex9 by analyzing PTS1 motifs and structural features, finding that hydrophobicity of the amino acid before the PTS1 tripeptide determines its binding specificity.

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

The paper identifies new peroxisomal functions in yeast by expanding the organellar proteome and analyzing sub-organellar localization and metabolic roles.

Bringing BOS to light: Uncovering the key enzyme in the biosynthesis of the neurotoxin β-ODAP in Grass Pea (Lathyrus sativus L.)

The paper identifies the enzyme BOS responsible for β-ODAP biosynthesis in grass pea, revealing its structure and function after over 50 years of research.

Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

This study quantifies mutational effects on binding affinity in three homologous protease-inhibitor complexes, revealing distinct binding landscapes and epistasis patterns.

Expression of a recombinant, 4’-Phosphopantetheinylated, active M. tuberculosis Fatty acid Synthase I in E. coli

This paper describes the expression and activation of Mtb FAS I in E. coli using AcpS, confirming its biochemical activity and structural properties.