J. T. Safrit

This study shows that therapeutic vaccination with a heterologous prime-boost regimen followed by N-803 treatment enhances CD8+ T cell responses in SIV-infected macaques.

This study shows that N-803 increases IFNγ production and alters MAIT cell trafficking in SIV+ macaques.

This study shows that N-803 treatment enhances CD8 T cell responses in SIV-infected macaques with low viral set-points, but not in those without prior immune control.

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

This study examines the correlation between neutralization breadth and infected-cell binding of broadly neutralizing antibodies against HIV reactivated from latent reservoirs.