R. B. Jones

Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV

This study evaluates the immunogenicity of COVID-19 vaccines in older people with HIV and their impact on HIV reservoirs, finding that three doses are needed for optimal neutralizing responses but vaccines may increase HIV reservoirs in those with persistent viremia.

Dynamic in vivo mapping of the methylproteome using a chemoenzymatic approach

This paper develops a chemoenzymatic method to map the methylproteome in vivo, identifying known and novel methylation sites across multiple organ systems in mice.

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

This study identifies ST6GAL1 sialyltransferase as a promoter of acinar-to-ductal metaplasia and pancreatic cancer progression through glycosylation-dependent mechanisms.

Epigenetic Memory of COVID-19 in Innate Immune Cells and Their Progenitors

The paper identifies sustained epigenomic changes in hematopoietic stem and progenitor cells after COVID-19, which influence innate immune cell function and inflammation.

Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer

This paper shows that combining PI3K and MLL1 inhibition enhances anti-tumor effects in HR+ breast cancer by disrupting a feedback loop between MLL1 and AKT.

HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy

The paper shows HIV-specific T-cell responses persist despite long-term ART, indicating ongoing recognition of infected cells and suggesting the reservoir is not fully immunologically silent.

Susceptibility to Neutralization by Broadly Neutralizing Antibodies Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs

This study examines the correlation between neutralization breadth and infected-cell binding of broadly neutralizing antibodies against HIV reactivated from latent reservoirs.