P. Soon-Shiong

A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

This paper develops a self-amplifying RNA vaccine against SARS-CoV-2 with room-temperature stability and strong immune responses in preclinical studies.

Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike

The paper analyzes HLA-I and HLA-II binding peptides in SARS-CoV-2 spike and nucleocapsid proteins across variants to assess T-cell epitope conservation and evasion potential.

Heteologous saRNA-Prime, DNA Dual-Antigen-Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

A deep learning-based iterative digital pathology annotation tool

This paper introduces a deep learning-based tool for digital pathology annotation that reduces annotation time while maintaining accuracy, validated on CAMELYON16 and TCGA datasets.

The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

A recombinant ACE2 Triple Decoy that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants

The paper develops an ACE2 Triple Decoy that maintains high affinity for SARS-CoV-2 variants and shows enhanced affinity for specific mutations.

Millisecond-scale molecular dynamics simulation of spike RBD structure reveals evolutionary adaption of SARS-CoV-2 to stably bind ACE2

The paper uses molecular dynamics simulations to study SARS-CoV-2 spike RBD interactions with ACE2, revealing an optimized binding conformation and potential targets for therapeutics.

Complete Protection of Nasal and Lung Airways Against SARS-CoV-2 Challenge by Antibody Plus Th1 Dominant N- and S-Specific T-Cell Responses to Subcutaneous Prime and Thermally-Stable Oral Boost Bivalent hAd5 Vaccination in an NHP Study

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

This study shows PD-L1 CAR-engineered NK cells kill cancer cells and inhibit tumor growth by targeting PD-L1, reducing myeloid cells in both preclinical models and patient blood.

Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples

The paper identifies a 32-gene immune signature in Treg-enriched tumor samples that correlates with chemosensitivity, overall survival, and immunogenic tumor microenvironment features.