Author

J. T. Seffernick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Lindert· 3 shared A. D. Rolland· 1 shared A. Spuches· 1 shared F. V. Petegem· 1 shared G. F. Tibbits· 1 shared J. P. Davis· 1 shared J. S. Prell· 1 shared K. Rayani· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

S. Lindert

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Author profile →

3 papers

Recent·Most cited

Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling

Z. C. Drake, J. T. Seffernick, S. Lindert

This paper introduces a hybrid method combining AlphaFold and Rosetta with covalent labeling data to improve protein complex structure prediction.

bioRxiv · Apr 30, 2022Biophysics

Protein shape sampled by ion mobility mass spectrometry consistently improves protein structure prediction

S. B. A. Turzo, J. T. Seffernick, A. D. Rolland, M. T. Donor, S. Heinze, J. S. Prell, V. H. Wysocki, S. Lindert

This study shows that ion mobility mass spectrometry data improve protein structure prediction using Rosetta, achieving better accuracy for 15 out of 23 benchmark proteins.

bioRxiv · May 27, 2021Biophysics

Binding of Calcium and Magnesium to Cardiac Troponin C

K. Rayani, J. T. Seffernick, Y. A. Li, J. P. Davis, A. Spuches, F. V. Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study quantifies Ca2+/Mg2+ binding to cardiac troponin C site II, showing Mg2+ can occupy site II and reduce Ca2+ affinity at physiological concentrations.

bioRxiv · Jun 14, 2020 · PreprintCell Biology