Author

K. Rayani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. F. Tibbits· 2 shared R. J. Solaro· 2 shared S. Lindert· 2 shared A. M. Spuches· 1 shared A. R. Watkins· 1 shared A. Spuches· 1 shared A. Y. Li· 1 shared D. Poburko· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

G. F. Tibbits

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Author profile →

3 papers

Recent·Most cited

The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants

K. Rayani, E. Hantz, O. Haji-Ghassemi, A. Y. Li, A. M. Spuches, F. Van Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study investigates how magnesium affects calcium binding to cardiac troponin C mutants linked to hypertrophic cardiomyopathy, showing that Mg2+ competes with Ca2+ and modifies binding affinity.

bioRxiv · May 12, 2021 · PreprintCell Biology

Mechanism and effects of the skeletal muscle Nav1.4 inhibition by cannabidiol

M.-R. Ghovanloo, K. Choudhury, T. S. Bandaru, M. A. Fouda, K. Rayani, R. Rusinova, T. Phaterpekar, K. Nelkenbrecher, A. R. Watkins, D. Poburko, J. Thewalt, O. S. Andersen, L. Delemotte, S. J. Goodchild, P. Ruben

This study investigates how cannabidiol inhibits Nav1.4 channels in skeletal muscle by modulating membrane elasticity and directly interacting with the channel pore.

bioRxiv · Jun 30, 2020Biophysics

Binding of Calcium and Magnesium to Cardiac Troponin C

K. Rayani, J. T. Seffernick, Y. A. Li, J. P. Davis, A. Spuches, F. V. Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study quantifies Ca2+/Mg2+ binding to cardiac troponin C site II, showing Mg2+ can occupy site II and reduce Ca2+ affinity at physiological concentrations.

bioRxiv · Jun 14, 2020 · PreprintCell Biology