Author

R. J. Solaro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

G. F. Tibbits· 3 shared S. Lindert· 3 shared A. Y. LI· 2 shared K. Rayani· 2 shared A. M. Cool· 1 shared A. M. Spuches· 1 shared A. Spuches· 1 shared B. M. Wolska· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

G. F. Tibbits

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development

S. Shafaattalab, A. Y. LI, Y. Maaref, F. Jayousi, S. Dababneh, H. Hamledari, D. H. Baygi, T. Barszczewski, B. Rupai, S. Jannati, R. Nagalingam, A. M. Cool, P. Langa, M. Chiao, T. Roston, , G. F. Tibbits

This study investigates the pathogenic mechanisms of the TNNT2 R278C+/- variant in cardiomyocytes using proteomics and functional assays, revealing its impact on cardiac function and arrhythmia.

bioRxiv · Jun 6, 2023 · PreprintCell Biology

Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart

E. H. Phillips, V. P. Bindokas, D. Jung, J. Teamer, J. K. Kitajewski, R. J. Solaro, B. M. Wolska, S. S.-Y. Lee

The paper develops a 3D lightsheet microscopy workflow and image analysis pipeline to study cardiac lymphatic vessel morphology in HCM mouse hearts, identifying pathological changes in the right atrium.

bioRxiv · Feb 1, 2023Pathology

The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants

K. Rayani, E. Hantz, O. Haji-Ghassemi, A. Y. Li, A. M. Spuches, F. Van Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study investigates how magnesium affects calcium binding to cardiac troponin C mutants linked to hypertrophic cardiomyopathy, showing that Mg2+ competes with Ca2+ and modifies binding affinity.

bioRxiv · May 12, 2021 · PreprintCell Biology

Binding of Calcium and Magnesium to Cardiac Troponin C

K. Rayani, J. T. Seffernick, Y. A. Li, J. P. Davis, A. Spuches, F. V. Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study quantifies Ca2+/Mg2+ binding to cardiac troponin C site II, showing Mg2+ can occupy site II and reduce Ca2+ affinity at physiological concentrations.

bioRxiv · Jun 14, 2020 · PreprintCell Biology